Adult Primary Care for the Advanced Practice Nurse (D118)

Ace NURS 6820 with Expert-Practice Questions – Unlimited Access for Just $30/Month
200+ High-Quality Practice Questions & Detailed Explanations Tailored for Adult Primary Care (D118)
Struggling to master the complexities of NURS 6820 Adult Primary Care for the Advanced Practice Nurse (D118)? ULOSCA gives you the edge with 200+ actual exam practice questions and detailed explanations—all designed to reinforce critical concepts and boost your confidence.
Why Choose ULOSCA?
-
Unlimited access to premium study resources for just $30/month
-
Realistic practice questions mirroring exam difficulty
-
Clear, in-depth explanations to solidify your understanding
-
Focused review on key topics for NURS 6820/D118
Subscribe now and start practicing with the best resources available.
Rated 4.8/5 from over 1000+ reviews
- Unlimited Exact Practice Test Questions
- Trusted By 200 Million Students and Professors
What’s Included:
- Unlock 100 + Actual Exam Questions and Answers for Adult Primary Care for the Advanced Practice Nurse (D118) on monthly basis
- Well-structured questions covering all topics, accompanied by organized images.
- Learn from mistakes with detailed answer explanations.
- Easy To understand explanations for all students.

Free Adult Primary Care for the Advanced Practice Nurse (D118) Questions
Which class of medications is known to potentially induce depressive symptoms in patients
-
Antibiotics and antiviral medications
-
Hormonal contraceptives
-
Non-steroidal anti-inflammatory drugs (NSAIDs)
-
Heart medications, blood pressure drugs, sedatives, antipsychotics, and steroids
Explanation
Correct answer: D. Heart medications, blood pressure drugs, sedatives, antipsychotics, and steroids
Explanation:
Certain medications, including beta-blockers, calcium channel blockers, sedatives, antipsychotics, and corticosteroids, have been linked to depressive symptoms. These drugs can alter neurotransmitter function, hormonal balance, or central nervous system activity, leading to mood disturbances. Corticosteroids, for example, can cause mood swings, while some antipsychotics and sedatives can contribute to emotional blunting or depressive symptoms. Physicians must monitor patients for changes in mood when prescribing these medications.
Why other options are wrong:
A. Antibiotics and antiviral medications
While some antibiotics, such as fluoroquinolones, have been associated with neuropsychiatric effects like anxiety or agitation, they are not commonly linked to inducing depressive symptoms. Antiviral medications also do not have a well-established association with depression, although some may cause fatigue or cognitive effects as side effects.
B. Hormonal contraceptives
Although some hormonal contraceptives have been reported to contribute to mood changes, including depression, the evidence remains mixed. Some studies suggest a link, particularly in sensitive individuals, but it is not strong enough to classify all hormonal contraceptives as depression-inducing. The effects may vary depending on the formulation, individual hormonal responses, and pre-existing mental health conditions.
C. Non-steroidal anti-inflammatory drugs (NSAIDs)
NSAIDs, such as ibuprofen and naproxen, are not generally known to cause depression. While long-term use of NSAIDs may be associated with gastrointestinal, renal, or cardiovascular side effects, there is no strong clinical evidence suggesting that these medications directly induce depressive symptoms. However, some studies have explored potential interactions between NSAIDs and psychiatric symptoms, but findings remain inconclusive.
If a patient reports significant impairment in their work performance and social relationships due to depressive symptoms, what would this indicate about their condition
-
It suggests they are experiencing a mild form of anxiety.
-
It indicates a functional impact of depression.
-
It implies they have no significant mental health issues.
-
It means they are likely suffering from a personality disorder.
Explanation
Correct Answer: B. It indicates a functional impact of depression.
Explanation:
Depressive symptoms that result in significant impairment in work performance and social relationships are indicative of the functional impact of depression. This impairment suggests that the individual's depression is severe enough to affect their daily life and quality of life, which is a common feature of major depressive disorder (MDD). The functional impact can be used to assess the severity of the disorder and guide treatment decisions.
Why other options are wrong:
A. It suggests they are experiencing a mild form of anxiety.
While anxiety symptoms can overlap with depression, work and social impairments due to depressive symptoms are more directly related to the functional impact of depression, not anxiety. Anxiety alone does not necessarily cause this level of impairment.
C. It implies they have no significant mental health issues.
This is incorrect. Depression is a significant mental health issue that can cause substantial disruptions in work performance and social interactions. The patient's symptoms are clearly affecting their daily life, which contradicts the idea that they have no significant mental health issues.
D. It means they are likely suffering from a personality disorder.
While personality disorders can affect relationships and functioning, the symptoms described here are more likely related to depression. Personality disorders typically involve persistent patterns of behavior and are not typically characterized by the sudden impairment seen in depression.
If a patient identifies specific warning signs of distress, how should this information be integrated into their safety plan
-
The warning signs should be documented and discussed to develop personalized coping strategies and support contacts.
-
The warning signs should be used to increase medication dosages.
-
The warning signs should be shared with family members without the patient’s consent.
-
The warning signs should be ignored as they are not relevant.
Explanation
Correct Answer: A. The warning signs should be documented and discussed to develop personalized coping strategies and support contacts
Explanation:
A safety plan is a structured approach designed to help individuals identify and manage distress before it escalates. When a patient recognizes specific warning signs, these should be documented and discussed with them to develop personalized coping strategies. This may include identifying supportive contacts, creating a list of distractions or calming activities, and knowing when to seek professional help. The safety plan helps empower the patient by providing them with concrete steps to take when they feel overwhelmed.
Why other options are wrong:
B. The warning signs should be used to increase medication dosages.
While medication may play a role in managing depression, simply increasing the dosage based on warning signs is not an appropriate immediate response. A holistic approach, including therapy and crisis intervention, should be prioritized.
C. The warning signs should be shared with family members without the patient’s consent.
While involving family can be helpful, it should only be done with the patient’s consent, unless there is an immediate risk of harm. Respecting the patient’s privacy and autonomy is essential to maintaining trust and effective care.
D. The warning signs should be ignored as they are not relevant.
Ignoring warning signs can lead to severe consequences, including increased distress or suicidal behavior. Recognizing and addressing these signs through a safety plan is crucial for preventing crises and improving patient outcomes.
Which substances are known to potentially trigger panic attacks
-
Antidepressants, benzodiazepines, and alcohol
-
Nicotine, heroin, and methamphetamine
-
Caffeine, cocaine, and alcohol
-
Caffeine, nicotine, and marijuana
Explanation
Correct Answer: C. Caffeine, cocaine, and alcohol
Explanation:
Certain substances are known to increase the risk of panic attacks by affecting the nervous system and mental state. Caffeine is a stimulant that can heighten anxiety and contribute to hyperarousal. Cocaine is a powerful stimulant that can provoke intense anxiety and panic symptoms. Alcohol is a depressant that can disrupt mood regulation and induce feelings of anxiety during withdrawal or after heavy consumption. Together, these substances can trigger or exacerbate panic attacks by altering brain chemistry.
Why other options are wrong:
A. Antidepressants, benzodiazepines, and alcohol
Antidepressants and benzodiazepines are typically used to treat anxiety and panic attacks, not trigger them. While alcohol can contribute to anxiety and panic, the other two substances generally calm the nervous system and reduce symptoms.
B. Nicotine, heroin, and methamphetamine
Although nicotine can induce anxiety, heroin and methamphetamine are substances that affect dopamine and opioid receptors but are more commonly associated with other mental health issues. These are not typical triggers for panic attacks.
D. Caffeine, nicotine, and marijuana
While nicotine and caffeine are known to increase the risk of panic, marijuana is more commonly linked to anxiety disorders, but not typically a primary trigger for panic attacks. Marijuana can exacerbate anxiety but is not as directly linked to panic attacks as caffeine and cocaine.
What are the key components of a safety plan for someone at lower risk of suicide
-
Medication management and therapy options.
-
Emergency contact numbers and a list of medications.
-
Daily journaling and exercise routines.
-
Identifying warning signs, developing coping strategies, and contacting support services.
Explanation
Correct answer: D. Identifying warning signs, developing coping strategies, and contacting support services.
Explanation:
A safety plan for someone at lower risk of suicide typically focuses on identifying early warning signs of distress, developing personalized coping strategies, and ensuring the individual knows how to reach out for support when needed. It is a proactive tool that helps individuals manage crises and provides them with a clear set of actions to take if they begin feeling suicidal. The goal is to empower the person to seek help and use coping mechanisms before the situation escalates.
Why other options are wrong:
A. Medication management and therapy options.
While medication management and therapy are important components of treatment for mental health conditions, they are not typically the focus of a safety plan for someone at lower risk of suicide. A safety plan is more about immediate, practical steps to manage a crisis.
B. Emergency contact numbers and a list of medications.
Emergency contacts and medication lists are important, but they are not the primary focus of a safety plan. The safety plan should be centered on coping mechanisms and strategies for managing crises, not just contact information.
C. Daily journaling and exercise routines.
Journaling and exercise can be helpful for mental well-being, but they are not core components of a safety plan. The safety plan should focus on immediate actions to take when someone is feeling at risk of self-harm.
If a patient with Major Depressive Disorder reports significant changes in sleep and appetite, what underlying physiological mechanism might be contributing to these symptoms
-
Improved emotional regulation
-
Enhanced cognitive function
-
Increased serotonin levels
-
Hypothalamic dysregulation
Explanation
Correct answer D. Hypothalamic dysregulation
Explanation:
The hypothalamus plays a crucial role in regulating sleep, appetite, and other autonomic functions. In Major Depressive Disorder (MDD), hypothalamic dysregulation can disrupt the body's normal sleep-wake cycle and appetite control, leading to symptoms such as insomnia or hypersomnia and increased or decreased appetite. This dysfunction is often linked to alterations in neurotransmitter activity, particularly serotonin, dopamine, and norepinephrine, which affect mood and physiological processes.
Why other options are wrong:
A. Improved emotional regulation
MDD is associated with impaired emotional regulation, not improvement. Emotional dysregulation can exacerbate symptoms such as sleep disturbances and appetite changes.
B. Enhanced cognitive function
Depression is typically linked to cognitive impairments, including difficulties with concentration, memory, and decision-making. Cognitive function is usually diminished rather than enhanced.
C. Increased serotonin levels
Serotonin levels are often lower in individuals with depression. While serotonin is involved in mood regulation, decreased serotonin activity is commonly associated with sleep disturbances and appetite changes in MDD.
What is the primary reason for implementing dietary restrictions when prescribing MAOIs
-
To prevent weight gain during treatment.
-
To enhance the effectiveness of the medication.
-
To reduce the risk of side effects from other medications.
-
High interaction risks with certain foods and medications.
Explanation
Correct answer: D. High interaction risks with certain foods and medications.
Explanation:
Monoamine oxidase inhibitors (MAOIs) require dietary restrictions to prevent dangerous interactions, particularly with tyramine-rich foods like aged cheeses, cured meats, and fermented products. Tyramine can trigger a hypertensive crisis when combined with MAOIs because these medications inhibit the enzyme that breaks it down. Additionally, MAOIs can interact with other medications, including antidepressants and decongestants, leading to severe side effects such as serotonin syndrome or dangerously high blood pressure.
Why other options are wrong:
A. To prevent weight gain during treatment.
While some medications may contribute to weight changes, dietary restrictions for MAOIs are primarily focused on avoiding dangerous hypertensive reactions rather than weight management.
B. To enhance the effectiveness of the medication.
Dietary restrictions do not increase the effectiveness of MAOIs; they are necessary to prevent harmful interactions. The medication's effectiveness is independent of dietary choices.
C. To reduce the risk of side effects from other medications.
While MAOIs interact with many medications, the primary concern with dietary restrictions is preventing hypertensive crises due to food interactions, not just medication side effects.
If a patient on lithium reports significant weight gain, what should be the clinician's next step in management
-
Refer the patient for weight loss surgery.
-
Evaluate the patient's diet and lifestyle, and consider adjusting the lithium dosage.
-
Increase the lithium dosage to counteract weight gain.
-
Immediately discontinue lithium treatment.
Explanation
Correct answer B. Evaluate the patient's diet and lifestyle, and consider adjusting the lithium dosage.
Explanation:
Weight gain is a common side effect of lithium therapy, and management should begin with a thorough assessment of the patient’s diet, physical activity, and overall metabolic health. The clinician should explore lifestyle modifications, such as dietary changes and increased physical activity, before considering any medication adjustments. If the weight gain is significant and affects the patient’s adherence to lithium, dose modification or switching to an alternative mood stabilizer may be considered.
Why other options are wrong:
A. Refer the patient for weight loss surgery.
Weight loss surgery is not an appropriate first-line intervention for lithium-induced weight gain. The patient should first attempt lifestyle changes and, if needed, medication adjustments under clinical supervision.
C. Increase the lithium dosage to counteract weight gain.
Increasing the lithium dosage does not counteract weight gain. In fact, higher lithium levels can exacerbate metabolic side effects. Instead, a more holistic approach involving dietary and lifestyle modifications should be prioritized.
D. Immediately discontinue lithium treatment.
Abruptly stopping lithium can lead to mood instability and relapse of bipolar disorder. Medication adjustments should only be made under careful clinical supervision, considering the risks and benefits of alternative treatments.
What are the four categories of symptoms required for a PTSD diagnosis
-
Physical symptoms, emotional numbness, social withdrawal, and cognitive distortions.
-
Reexperiencing symptoms, avoidance symptoms, cognition and mood symptoms, and arousal and reactivity symptoms.
-
Anxiety symptoms, mood swings, sleep disturbances, and compulsive behaviors.
-
Hallucinations, delusions, disorganized thinking, and negative symptoms.
Explanation
Correct answer: B. Reexperiencing symptoms, avoidance symptoms, cognition and mood symptoms, and arousal and reactivity symptoms
Explanation:
The four symptom categories for PTSD, as defined in the DSM-5, include:
Reexperiencing symptoms – Includes flashbacks, nightmares, and intrusive thoughts related to the traumatic event.
Avoidance symptoms – Avoiding reminders of the trauma, such as people, places, or thoughts.
Cognition and mood symptoms – Includes negative thoughts, memory problems related to the trauma, feelings of guilt, or emotional numbness.
Arousal and reactivity symptoms – Increased startle response, difficulty sleeping, hypervigilance, and irritability.
Why other options are wrong:
A. Physical symptoms, emotional numbness, social withdrawal, and cognitive distortions.
While some of these symptoms can be present in PTSD, they do not reflect the official diagnostic criteria. PTSD involves specific clusters of symptoms beyond just these elements.
C. Anxiety symptoms, mood swings, sleep disturbances, and compulsive behaviors.
These symptoms are associated with various mental health conditions, including PTSD, but they do not define the four key symptom categories required for diagnosis.
D. Hallucinations, delusions, disorganized thinking, and negative symptoms.
These symptoms are characteristic of psychotic disorders, such as schizophrenia, rather than PTSD.
Describe how cannabis use can affect heart rate and blood pressure in the short term
-
Cannabis use has no effect on heart rate or blood pressure.
-
Cannabis use can lead to an increased heart rate and low blood pressure.
-
Cannabis use stabilizes heart rate and raises blood pressure.
-
Cannabis use decreases heart rate and increases blood pressure.
Explanation
Correct answer: B. Cannabis use can lead to an increased heart rate and low blood pressure.
Explanation:
In the short term, cannabis use can cause an increase in heart rate (tachycardia) while simultaneously leading to a drop in blood pressure. This occurs because cannabinoids affect the autonomic nervous system, leading to vasodilation (widening of blood vessels), which lowers blood pressure. To compensate, the heart may beat faster. This effect is most noticeable in new or infrequent users and may contribute to dizziness or lightheadedness.
Why other options are wrong:
A. Cannabis use has no effect on heart rate or blood pressure.
This is incorrect because cannabis has been shown to have physiological effects on the cardiovascular system, particularly increasing heart rate and lowering blood pressure.
C. Cannabis use stabilizes heart rate and raises blood pressure.
This is incorrect because cannabis does not stabilize heart rate; rather, it typically increases it. Additionally, it usually causes a drop in blood pressure rather than raising it.
D. Cannabis use decreases heart rate and increases blood pressure.
This is incorrect because cannabis use is more commonly associated with an increased heart rate and a decrease in blood pressure rather than the opposite.
How to Order
Select Your Exam
Click on your desired exam to open its dedicated page with resources like practice questions, flashcards, and study guides.Choose what to focus on, Your selected exam is saved for quick access Once you log in.
Subscribe
Hit the Subscribe button on the platform. With your subscription, you will enjoy unlimited access to all practice questions and resources for a full 1-month period. After the month has elapsed, you can choose to resubscribe to continue benefiting from our comprehensive exam preparation tools and resources.
Pay and unlock the practice Questions
Once your payment is processed, you’ll immediately unlock access to all practice questions tailored to your selected exam for 1 month .
NURS 6820 Adult Primary Care for the Advanced Practice Nurse (D118) Study Notes
Table of Contents
- Introduction to Adult Primary Care
- Health Promotion and Disease Prevention
- Common Adult Health Conditions
- Hypertension
- Diabetes Mellitus
- Hyperlipidemia
- Chronic Disease Management
- Asthma
- Chronic Obstructive Pulmonary Disease (COPD)
- Mental Health in Primary Care
- Depression
- Anxiety
- Women’s Health
- Menopause
- Contraception
- Men’s Health
- Benign Prostatic Hyperplasia (BPH)
- Erectile Dysfunction
- Geriatric Care
- Polypharmacy
- Fall Prevention
- Acute Conditions in Primary Care
- Upper Respiratory Infections (URI)
- Urinary Tract Infections (UTI)
- Evidence-Based Practice
- Case Studies with Analysis
- Case Study 1: Hypertension Management
- Case Study 2: Diabetes Management
- Conclusion and Study Pack Benefits
1. Introduction to Adult Primary Care
Adult primary care focuses on the prevention, diagnosis, and management of health conditions in adults. Advanced Practice Nurses (APNs) play a critical role in providing holistic, patient-centered care. Key responsibilities include health promotion, disease prevention, and patient education.
Key Skills for APNs:
- Clinical reasoning
- Evidence-based practice
- Effective communication
2. Health Promotion and Disease Prevention
Health promotion and disease prevention are foundational in adult primary care. APNs must be familiar with screening guidelines and lifestyle interventions.
Screening Guidelines:
- Cardiovascular Health: Screen for hypertension, hyperlipidemia, and diabetes.
- Cancer Screening: Recommend mammograms, colonoscopies, and Pap smears based on age and risk factors.
- Immunizations: Ensure patients are up-to-date on vaccines like influenza, pneumococcal, and HPV.
Lifestyle Modifications:
- Encourage smoking cessation, weight management, and regular physical activity.
Example: A 45-year-old male with a BMI of 32 should be counseled on weight loss strategies and screened for diabetes and hypertension.
3. Common Adult Health Conditions
Hypertension
- Diagnosis: BP ≥130/80 mmHg on two separate occasions.
- Management:
- Lifestyle changes: DASH diet, sodium restriction, and exercise.
- Medications: ACE inhibitors (e.g., lisinopril), beta-blockers, or diuretics.
Example: A 50-year-old male with a BP of 150/95 mmHg should be started on lisinopril and advised to follow a DASH diet.
Diabetes Mellitus
- Diagnosis: Fasting glucose ≥126 mg/dL or HbA1c ≥6.5%.
- Management:
- Medications: Metformin, insulin therapy.
- Patient education: Glucose monitoring, diet, and exercise.
Example: A 45-year-old female with a fasting glucose of 140 mg/dL should be started on metformin and referred to a dietitian.
Hyperlipidemia
- Diagnosis: LDL >160 mg/dL.
- Management:
- Medications: Statins (e.g., atorvastatin).
- Lifestyle changes: Low-fat diet and exercise.
Example: A 55-year-old male with an LDL of 170 mg/dL should be started on atorvastatin and advised to follow a low-fat diet.
4. Chronic Disease Management
Asthma
- Symptoms: Wheezing, shortness of breath, and cough.
- Management:
- Medications: Inhaled corticosteroids (e.g., fluticasone) and bronchodilators (e.g., albuterol).
- Patient education: Trigger avoidance and proper inhaler use.
Example: A 30-year-old female with asthma should be prescribed a maintenance inhaler and a rescue inhaler.
Chronic Obstructive Pulmonary Disease (COPD)
- Symptoms: Chronic cough, sputum production, and dyspnea.
- Management:
- Medications: Long-acting bronchodilators (e.g., tiotropium).
- Lifestyle changes: Smoking cessation and pulmonary rehabilitation.
Example: A 60-year-old smoker with COPD should be advised to quit smoking and prescribed tiotropium.
5. Mental Health in Primary Care
Depression
- Symptoms: Persistent sadness, loss of interest, and fatigue.
- Management:
- Medications: SSRIs (e.g., sertraline).
- Psychotherapy: Cognitive-behavioral therapy (CBT).
Example: A 35-year-old female with depression should be screened for suicidal ideation and started on sertraline.
Anxiety
- Symptoms: Excessive worry, restlessness, and palpitations.
- Management:
- Medications: Benzodiazepines (short-term) and SSRIs.
- Psychotherapy: CBT.
Example: A 25-year-old male with anxiety should be prescribed a short-term benzodiazepine and referred for CBT.
6. Women’s Health
Menopause
- Symptoms: Hot flashes, night sweats, and vaginal dryness.
- Management:
- Hormone replacement therapy (HRT).
- Lifestyle changes: Regular exercise and a healthy diet.
Example: A 50-year-old woman experiencing hot flashes may benefit from low-dose HRT.
Contraception
- Options: Oral contraceptives, IUDs, and condoms.
- Counseling: Discuss efficacy, side effects, and patient preferences.
Example: A 28-year-old female seeking contraception should be educated on the benefits and risks of IUDs.
7. Men’s Health
Benign Prostatic Hyperplasia (BPH)
- Symptoms: Urinary frequency, hesitancy, and weak stream.
- Management:
- Medications: Alpha-blockers (e.g., tamsulosin).
- Surgical options: Transurethral resection of the prostate (TURP).
Example: A 55-year-old male with BPH should be started on tamsulosin.
Erectile Dysfunction
- Symptoms: Inability to achieve or maintain an erection.
- Management:
- Medications: PDE5 inhibitors (e.g., sildenafil).
- Lifestyle changes: Weight loss and smoking cessation.
Example: A 60-year-old male with erectile dysfunction should be prescribed sildenafil and advised to quit smoking.
8. Geriatric Care
Polypharmacy
- Risks: Drug interactions and adverse effects.
- Management: Regular medication review and deprescribing.
Example: An 80-year-old patient on multiple medications should have a comprehensive medication review.
Fall Prevention
- Strategies: Home safety modifications and balance exercises.
- Example: A 75-year-old female with a history of falls should be referred to physical therapy.
9. Acute Conditions in Primary Care
Upper Respiratory Infections (URI)
- Symptoms: Cough, sore throat, and nasal congestion.
- Management: Symptomatic treatment (e.g., acetaminophen, hydration).
Example: A 25-year-old male with a URI should be advised to rest and stay hydrated.
Urinary Tract Infections (UTI)
- Symptoms: Dysuria, frequency, and urgency.
- Management: Antibiotics (e.g., nitrofurantoin) and increased fluid intake.
Example: A 30-year-old female with dysuria should be tested for UTI and treated with nitrofurantoin.
10. Evidence-Based Practice
- Importance: Integrating clinical expertise with the best available evidence.
- Example: Using the latest guidelines for hypertension management to optimize patient outcomes.
11. Case Studies with Analysis
Case Study 1: Hypertension Management
- Scenario: A 50-year-old male with a BP of 150/95 mmHg.
- Plan: Lifestyle changes and lisinopril.
- Analysis: Early intervention prevents complications.
Case Study 2: Diabetes Management
- Scenario: A 45-year-old female with a fasting glucose of 140 mg/dL.
- Plan: Metformin and lifestyle changes.
- Analysis: Comprehensive management prevents long-term complications.
12. Conclusion and Study Pack Benefits
- Key Takeaways: Adult primary care requires a holistic approach.
- Study Pack Benefits: 100 Q&A with rationales for $30/month.
- Why Choose ulosca.com?: Guaranteed 100% pass rate in proctored exams.
Sample Practice Questions and Answers
Question 1:
A 58-year-old male patient presents with fatigue, unintentional weight loss, and persistent epigastric discomfort. He reports occasional dark stools. His medical history includes hypertension and chronic NSAID use for osteoarthritis. What is the most likely diagnosis?
Explanation:
Peptic ulcer disease (PUD) is the most likely diagnosis given the patient’s history and symptoms. PUD results from mucosal erosion due to an imbalance between protective and aggressive gastric factors. Key risk factors include chronic NSAID use, Helicobacter pylori infection, smoking, and stress. The symptoms of epigastric discomfort, fatigue, weight loss, and melena (dark stools indicating GI bleeding) strongly suggest ulcer formation.
- NSAID use: NSAIDs inhibit prostaglandin synthesis, reducing gastric mucosal protection and increasing susceptibility to acid-induced injury.
- Melena: Indicates potential upper gastrointestinal bleeding, common in complicated ulcers.
- Epigastric discomfort: A hallmark of PUD, often relieved by antacids or worsened with food, depending on ulcer location (gastric vs. duodenal).
- Weight loss and fatigue: Suggest complications such as chronic bleeding and anemia.
- GERD is primarily caused by lower esophageal sphincter dysfunction, leading to reflux of acidic gastric contents into the esophagus.
- Why is it incorrect? GERD typically presents with heartburn, regurgitation, and dysphagia, not dark stools or weight loss. While GERD can cause epigastric discomfort, it does not explain the patient’s melena, which suggests an active upper GI bleed.
- Gastric cancer can present with weight loss, epigastric discomfort, and GI bleeding, making it a potential differential diagnosis.
- Why is it incorrect? While the symptoms overlap, PUD is far more common than gastric cancer. The absence of additional red flag symptoms such as a palpable abdominal mass, persistent vomiting, or severe anorexia makes PUD the more likely diagnosis. A biopsy would be required to confirm gastric malignancy.
- IBS is a functional gastrointestinal disorder characterized by chronic abdominal pain, bloating, and altered bowel habits (diarrhea, constipation, or both) without structural abnormalities.
- Why is it incorrect? IBS does not cause melena, weight loss, or fatigue, as it is not associated with gastrointestinal bleeding or systemic symptoms. The presence of black stools suggests a serious pathology like an ulcer rather than IBS.
Question 2:
A 65-year-old female patient with a history of type 2 diabetes and hypertension presents with progressive exertional dyspnea, orthopnea, and bilateral lower extremity edema. On examination, she has jugular venous distension (JVD), rales on lung auscultation, and an S3 heart sound. What is the most likely diagnosis?
CHF is the most likely diagnosis given the history of exertional dyspnea, orthopnea, lower extremity edema, JVD, rales, and an S3 heart sound. These findings are characteristic of left-sided and right-sided heart failure.
- Dyspnea and orthopnea: Result from pulmonary congestion due to increased left atrial and pulmonary venous pressure.
- Bilateral lower extremity edema and JVD: Indicate right-sided heart failure, where blood backs up into the systemic circulation.
- Rales (crackles) on lung auscultation: Suggest pulmonary congestion/edema due to left ventricular dysfunction.
- S3 heart sound ("ventricular gallop"): Signifies volume overload and poor ventricular compliance, common in CHF.
CHF can be caused by long-term hypertension, coronary artery disease, and diabetes, all of which are risk factors in this patient.
Why the Other Options Are Incorrect:
- COPD presents with chronic cough, wheezing, sputum production, and exertional dyspnea due to airflow obstruction.
- Why is it incorrect? This patient lacks a history of smoking or chronic bronchitis and does not have wheezing or prolonged expiratory phase, which are hallmarks of COPD. Also, COPD does not cause JVD, edema, or an S3 heart sound, which point to CHF.
- PE typically presents with sudden onset dyspnea, pleuritic chest pain, tachycardia, and possibly hemoptysis.
- Why is it incorrect? PE is acute in onset, whereas this patient has progressive symptoms over time. Additionally, PE does not typically cause bilateral edema or JVD.
- CKD often presents with edema, fatigue, anorexia, and metabolic abnormalities (e.g., hyperkalemia, acidosis).
- Why is it incorrect? While CKD can cause fluid retention and hypertension, it does not explain the pulmonary congestion (rales) and S3 heart sound, which strongly indicate cardiac dysfunction rather than renal failure.
Question 3:
A 72-year-old male patient with a history of atrial fibrillation (AF), hypertension, and type 2 diabetes presents with sudden-onset left-sided weakness, slurred speech, and facial drooping. His symptoms started 1.5 hours ago. On examination, he has left-sided hemiparesis, facial asymmetry, and difficulty speaking. What is the most appropriate next step in management?
A. Administer aspirin immediately
B. Obtain a non-contrast CT scan of the head
C. Start anticoagulation with heparin
D. Perform carotid ultrasound to assess stenosis
Correct Answer:
B. Obtain a Non-Contrast CT Scan of the Head
Explanation:
The patient’s acute-onset neurological deficits (hemiparesis, facial droop, and speech difficulty) suggest an acute ischemic stroke, likely embolic due to atrial fibrillation.
- The first and most critical step in stroke management is to obtain a non-contrast CT scan to rule out hemorrhagic stroke before considering thrombolytic therapy.
- Time-sensitive intervention: Since symptoms started 1.5 hours ago (within the 4.5-hour window for tissue plasminogen activator [tPA] administration), rapid imaging is crucial to determine eligibility.
- Why non-contrast CT? It quickly identifies intracranial hemorrhage (ICH), which is a contraindication to tPA.
Why the Other Options Are Incorrect:
A. Administer aspirin immediately
- Aspirin is used for secondary stroke prevention in ischemic stroke, but it should not be given before ruling out hemorrhagic stroke.
- Why is it incorrect? If the stroke is hemorrhagic, aspirin could worsen bleeding. Thrombolysis (tPA) is preferred for eligible ischemic stroke patients within the 4.5-hour window.
C. Start anticoagulation with heparin
- Anticoagulation (e.g., heparin, warfarin, or DOACs) is used long-term for atrial fibrillation to prevent strokes, but it is not used in the acute setting of an active stroke.
- Why is it incorrect? Immediate anticoagulation increases the risk of hemorrhagic transformation in acute ischemic stroke.
D. Perform carotid ultrasound to assess stenosis
- Carotid artery stenosis is a major risk factor for ischemic stroke, and carotid ultrasound is used for secondary prevention.
- Why is it incorrect? It does not guide acute stroke management. The priority is brain imaging to determine if thrombolysis is an option. Carotid ultrasound is more useful in transient ischemic attacks (TIAs) or non-urgent stroke workups.
Question 4:
A 55-year-old female with a history of rheumatoid arthritis (RA) and chronic steroid use presents with severe low back pain, worsened by movement and unrelieved by rest. She denies trauma but reports gradual height loss over the past year. On examination, she has point tenderness over the thoracic spine but no neurological deficits. What is the most likely diagnosis?
A. Lumbar disc herniation
B. Vertebral compression fracture
C. Ankylosing spondylitis
D. Degenerative disc disease
Correct Answer:
B. Vertebral Compression Fracture
Explanation:
The most likely diagnosis is a vertebral compression fracture (VCF) due to osteoporosis secondary to chronic steroid use (glucocorticoid-induced osteoporosis).
- Chronic steroid use is a major risk factor for osteoporosis, increasing the likelihood of compression fractures.
- Back pain that worsens with movement and improves with rest is classic for compression fractures.
- Gradual height loss suggests vertebral body collapse due to multiple fractures over time.
- Point tenderness over the thoracic spine is a key physical exam finding, as VCFs commonly affect the thoracic and lumbar vertebrae.
Why the Other Options Are Incorrect:
A. Lumbar Disc Herniation
- Usually presents with radicular pain (sciatica), numbness, and weakness due to nerve root compression.
- Why is it incorrect? This patient lacks neurological deficits (e.g., leg weakness, sensory loss, reflex changes), making disc herniation unlikely.
C. Ankylosing Spondylitis (AS)
- A chronic inflammatory condition that presents with insidious onset of low back pain, morning stiffness, and improvement with activity.
- Why is it incorrect? This patient’s pain is worsened by movement and unrelieved by rest, which is inconsistent with AS. Also, AS typically affects younger males (onset before 40).
D. Degenerative Disc Disease (DDD)
- Characterized by chronic back pain, stiffness, and gradual progression over years.
- Why is it incorrect? DDD does not cause acute vertebral tenderness or sudden height loss.
Key Takeaways:
- Vertebral compression fractures are common in osteoporosis, especially in postmenopausal women or patients on chronic steroids.
- Back pain + height loss + spinal tenderness = Strong suspicion for VCF.
- Diagnosis: Confirmed with spine X-ray or MRI (to rule out malignancy).
- Management: Pain control, bracing, physical therapy, and in severe cases, vertebroplasty or kyphoplasty.